Understanding how ribosomes manage quality control at the endoplasmic reticulum
Official title: The role of UFMylation in ribosome quality control at the ER
Funded at Stanford University · NIH-10991832 · Data updated 2026-11-12
This study is looking at how our cells keep their protein-making machines, called ribosomes, working properly, especially when they get stuck and might create harmful proteins, which could help us find new ways to treat diseases related to protein problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | January 1, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $524,383 |
| NIH project number | 5R01GM148477-03 |
| Project ID | NIH-10991832 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to protein misfolding or ribosome dysfunction.
✕Less likely to help
Patients with conditions unrelated to ribosome quality control or protein synthesis may not benefit from this research.
What this research studies
This research investigates the mechanisms by which ribosomes, the cellular machines that synthesize proteins, maintain their quality control, particularly at the endoplasmic reticulum (ER). It focuses on a process called UFMylation, which is crucial for managing stalled ribosomes that can produce harmful proteins. By studying how ribosomes adapt to challenges during protein synthesis, the research aims to uncover new insights into cellular health and the prevention of diseases linked to protein misfolding. Patients may benefit from a better understanding of these processes, which could lead to novel therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases caused by protein misfolding and ribosome dysfunction.
How similar studies have gone: Other research has shown success in understanding ribosome quality control mechanisms, but the specific focus on UFMylation at the ER is relatively novel.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Kopito, Ron R — Stanford University
- Study coordinator: Kopito, Ron R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.