Understanding how ribosomes influence gene expression
A Genetic Circuit Formed by Ribosomes
This study is looking at how ribosomes, which help make proteins, can influence how our genes work, especially when cells are under stress, like when they don't have enough nutrients, and it’s for anyone interested in understanding how our bodies adapt to tough situations.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10886558 on NIH RePORTER |
What this research studies
This research investigates the relationship between ribosomes and gene expression, particularly how ribosomes can affect transcription in the nucleus after translating mRNA in the cytoplasm. The study focuses on the mechanisms by which ribosomes communicate with the genetic material to regulate gene activity, especially under stress conditions like amino acid starvation. Using a novel sequencing method called Ezra-seq, researchers aim to identify ribosome footprints that may act as regulators of chromatin and gene expression. This could lead to new insights into how cells adapt to stress and maintain genetic stability.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to gene expression dysregulation, such as certain cancers or metabolic disorders like diabetes.
Not a fit: Patients with stable genetic conditions that do not involve dysregulation of gene expression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to gene regulation, including various cancers and metabolic disorders.
How similar studies have performed: While the specific approach of mapping ribosome footprints in relation to gene expression is novel, similar studies have shown promise in understanding gene regulation mechanisms.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Qian, Shu-Bing — Cornell University
- Study coordinator: Qian, Shu-Bing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.