Understanding how ribosomes in a fungus respond to stress
Ribosome Heterogeneity in Cryptococcus neoformans
['FUNDING_R01'] · STATE UNIVERSITY OF NEW YORK AT BUFFALO · NIH-10898924
This study is looking at how a fungus called Cryptococcus neoformans, which can make people with weakened immune systems very sick, changes its ribosomes to survive in the body during infections, with the goal of finding new ways to treat these infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY OF NEW YORK AT BUFFALO (nih funded) |
| Locations | 1 site (AMHERST, UNITED STATES) |
| Trial ID | NIH-10898924 on ClinicalTrials.gov |
What this research studies
This research investigates the ribosomes of the fungus Cryptococcus neoformans, which can cause serious infections in immunocompromised patients. It aims to identify how these ribosomes adapt to stress conditions that occur in the human body, particularly during infection. By exploring specific proteins that interact with the ribosome, the research seeks to uncover new targets for antifungal therapies. The study employs advanced techniques to analyze ribosomal behavior and its implications for drug resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with weakened immune systems, such as those undergoing transplantation or living with HIV/AIDS, who are at risk for invasive fungal infections.
Not a fit: Patients with fungal infections caused by organisms other than Cryptococcus neoformans may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antifungal treatments that are more effective against resistant strains of Cryptococcus neoformans.
How similar studies have performed: Previous research has successfully targeted ribosomal functions in other organisms, suggesting that this approach may yield promising results for antifungal therapy development.
Where this research is happening
AMHERST, UNITED STATES
- STATE UNIVERSITY OF NEW YORK AT BUFFALO — AMHERST, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PANEPINTO, JOHN C — STATE UNIVERSITY OF NEW YORK AT BUFFALO
- Study coordinator: PANEPINTO, JOHN C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.