Understanding how ribosomes control protein production
Official title: Ribosome regulation, inhibition, and quality control mechanisms
Funded at Emory University · NIH-11011735 · Data updated 2026-11-12
This study is looking at how ribosomes, the tiny machines in our cells that make proteins, work to make sure they do their job correctly, which could help develop new treatments for diseases caused by mistakes in protein production.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $316,968 |
| NIH project number | 1R35GM156629-01 |
| Project ID | NIH-11011735 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or diseases linked to protein synthesis dysfunction.
✕Less likely to help
Patients with conditions unrelated to protein synthesis or ribosomal function may not receive any benefit from this research.
What this research studies
This research investigates the complex mechanisms by which ribosomes, the cellular machinery responsible for protein synthesis, regulate and ensure the accuracy of translating genetic information into proteins. By employing advanced biochemistry and structural biology techniques, the study focuses on three main areas: the fidelity of translation, the rescue of stalled ribosomes, and the role of bacterial ribonucleases in inhibiting translation. Patients may benefit from insights gained into these processes, which could lead to new therapeutic strategies for diseases related to protein synthesis errors.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases caused by errors in protein synthesis.
How similar studies have gone: Other research has shown promising results in understanding ribosome function and its implications for disease, indicating that this area of study is both relevant and potentially impactful.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Dunham, Christine M — Emory University
- Study coordinator: Dunham, Christine M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.