Understanding how ribosomes are made in human cells
Novel regulatory networks driving human ribosome biogenesis
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-11046572
This study is looking at how our cells make ribosomes, which are important for cell health and growth, to better understand how problems in this process can lead to genetic diseases, especially certain conditions that affect development.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11046572 on ClinicalTrials.gov |
What this research studies
This research investigates the processes involved in ribosome biogenesis, which is crucial for cell function and development. By using advanced imaging techniques and cellular assays, the study aims to identify the regulatory networks that control ribosome production in various human tissues and cell types. The research focuses on understanding how disruptions in ribosome formation can lead to genetic diseases, particularly congenital conditions known as ribosomopathies. Through genome-wide screening, the project seeks to uncover new proteins and non-coding RNAs that play a role in this essential biological process.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital abnormalities or genetic diseases associated with ribosome biogenesis.
Not a fit: Patients with conditions unrelated to ribosome function or those who do not have congenital abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential therapies for genetic diseases related to ribosome dysfunction.
How similar studies have performed: Other research has shown success in understanding ribosome biogenesis in model organisms, but this approach in human cells is relatively novel.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BASERGA, SUSAN J — YALE UNIVERSITY
- Study coordinator: BASERGA, SUSAN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers