Understanding how ribosomes are made and regulated in cells
Regulation of Ribosome Biogenesis
This study is looking at how our cells make the building blocks needed for proteins, especially when they're under stress from things like medication or environmental factors, to help us understand how this process affects health and disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10906205 on NIH RePORTER |
What this research studies
This research investigates the complex process of ribosome biogenesis, which is essential for protein production in human cells. It focuses on how ribosomal RNA and proteins are assembled, particularly in response to various stressors like oxidative stress and certain medications. By employing a multi-omics approach, the study aims to uncover the regulatory pathways involved in ribosome assembly and how disruptions in this process can affect cellular function. Patients may benefit from insights gained about ribosome function in relation to diseases and treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that may involve ribosome biogenesis issues, such as certain cancers or genetic disorders.
Not a fit: Patients with conditions unrelated to ribosome function or those not experiencing any ribosomal biogenesis issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to ribosome dysfunction.
How similar studies have performed: Other research has shown promising results in understanding ribosome regulation and its implications for disease, indicating that this approach has potential for significant findings.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Lyons, Shawn M — Boston University Medical Campus
- Study coordinator: Lyons, Shawn M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.