Understanding how ribosomes are built in cells
Official title: Mechanisms of ribosome assembly
Funded at Rockefeller University · NIH-11011854 · Data updated 2026-11-12
This study is exploring how ribosomes, the tiny machines that help make proteins in our cells, come together in the early stages, using advanced imaging and technology to better understand this important process.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 17, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $678,000 |
| NIH project number | 1R35GM156426-01 |
| Project ID | NIH-11011854 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with hematologic diseases or genetic disorders that may be linked to ribosome assembly issues.
✕Less likely to help
Patients with conditions unrelated to ribosome function or assembly may not benefit from this research.
What this research studies
This research investigates the complex process of ribosome assembly, which is crucial for protein synthesis in all cells. By using advanced techniques such as cryo-electron microscopy and artificial intelligence, the project aims to capture detailed snapshots of the assembly process at a molecular level. The study focuses on the early stages of ribosome assembly that occur in the nucleolus, which are not well understood. Through a combination of genetic, biochemical, and mass spectrometry methods, the researchers hope to uncover the mechanisms that guide this essential cellular process.
Why it matters
Potential benefit: If successful, this research could lead to new insights into blood disorders and other diseases related to ribosome assembly defects.
How similar studies have gone: While the specific focus on early ribosome assembly is novel, related research has shown success in understanding ribosome function and its implications in various diseases.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Klinge, Sebastian — Rockefeller University
- Study coordinator: Klinge, Sebastian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.