Understanding how ribosomes affect cell changes in the gastrointestinal tract
Official title: THE ROLE OF RIBOSOMES IN METAPLASIA IN THE GASTROINTESTINAL TRACT
Funded at Emory University · NIH-11280918 · Data updated 2026-11-12
This study is looking at how tiny structures in our cells, called ribosomes, change when certain cells in the gut transform, which could help us understand gut diseases and find new treatments for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | April 4, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $155,693 |
| NIH project number | 7K01DK137030-02 |
| Project ID | NIH-11280918 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with gastrointestinal conditions, particularly those involving metaplasia or related cellular changes.
✕Less likely to help
Patients with non-gastrointestinal conditions or those not experiencing any cellular changes in the gastrointestinal tract may not benefit from this research.
What this research studies
This research investigates the role of ribosomes in the process of metaplasia, specifically focusing on zymogenic cells in the gastrointestinal tract. The study aims to understand how ribosomes are regulated during this cellular transformation and how it relates to regeneration and the development of tumors. Patients may benefit from insights gained about the mechanisms of gastrointestinal diseases and potential new therapeutic targets. The research will utilize advanced laboratory techniques, including confocal microscopy and cell culture, to explore these cellular processes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for gastrointestinal diseases and improved understanding of tumor development.
How similar studies have gone: Previous research has shown promising results in understanding cellular processes related to metaplasia, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Cho, Charles J — Emory University
- Study coordinator: Cho, Charles J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.