Understanding how ribosome production affects facial development in embryos and newborns
Official title: The role of rRNA transcription and ribosome biogenesis in neural crest progenitors and stem cells during embryonic and postnatal craniofacial development
Funded at Stowers Institute for Medical Research · NIH-11014348 · Data updated 2026-11-12
This study is looking at how certain processes in cells help shape the face during development, especially for those who might have craniofacial issues, to find ways to prevent these conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stowers Institute for Medical Research NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $79,692 |
| NIH project number | 5F32DE033617-02 |
| Project ID | NIH-11014348 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals under 21 years old with craniofacial anomalies or related congenital disorders.
✕Less likely to help
Patients with craniofacial conditions not linked to neural crest cell development may not benefit from this research.
What this research studies
This research investigates the role of ribosomal RNA transcription and ribosome biogenesis in neural crest progenitors and stem cells, which are crucial for craniofacial development. By examining how these processes influence the formation and migration of neural crest cells during embryonic and postnatal stages, the study aims to uncover the underlying mechanisms that lead to craniofacial anomalies. The research employs advanced molecular biology techniques to analyze the effects of disruptions in ribosome production on cell survival and differentiation. This could lead to insights into potential preventative therapies for congenital craniofacial disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for individuals with craniofacial anomalies.
How similar studies have gone: Previous research has shown promising results in understanding the role of ribosome biogenesis in cell development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Stowers Institute for Medical Research
Kansas City, United States Active
Researchers
- Principal investigator: Maili, Lorena — Stowers Institute for Medical Research
- Study coordinator: Maili, Lorena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.