Understanding how ribosome collisions affect health and disease
Regulation of ribosome collisions during health, development and disease
This study is looking at how bumps between tiny protein-making machines in our cells can affect our health, especially in brain diseases, and aims to find out how these bumps happen and what they mean for brain cell function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-11031075 on NIH RePORTER |
What this research studies
This research investigates how collisions between ribosomes on messenger RNA (mRNA) can impact cellular health and contribute to diseases, particularly neurodegenerative disorders. By using a technique called Disome-seq, the study aims to map where these collisions occur across the genome and how they trigger stress responses in cells. The researchers will explore the balance of ribosome collisions and their effects on neuronal function and differentiation, which could lead to new insights into the mechanisms behind certain neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental or neurodegenerative disorders, such as Charcot-Marie-Tooth disease.
Not a fit: Patients with conditions unrelated to ribosome function or those without neurodegenerative disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurodegenerative diseases by targeting ribosome collision mechanisms.
How similar studies have performed: While the specific approach of studying ribosome collisions is relatively novel, similar research has shown promising results in understanding cellular stress responses in other contexts.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Meydan Marks, Fatma Sezen — Vanderbilt University
- Study coordinator: Meydan Marks, Fatma Sezen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.