Understanding how ribosomal RNA production is regulated in different tissues
Regulation of rRNA transcription in mammalian tissues
This study is looking at how different types of cells in the body manage the production of ribosomes, which are essential for making proteins, and it aims to find out how this process might be connected to diseases like cancer and developmental disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10895381 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that control ribosomal RNA (rRNA) transcription in various mammalian tissues. By using advanced techniques like quantitative proteomics and transcription factor mapping in mouse models, the study aims to uncover how different cell types regulate ribosome production according to their specific needs. The research focuses on identifying key proteins and factors involved in this process, which could lead to a better understanding of diseases linked to ribosome biogenesis, such as certain cancers and developmental disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to ribosome biogenesis disorders, such as specific cancers or developmental abnormalities.
Not a fit: Patients with unrelated health conditions or those not affected by ribosome biogenesis disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the treatment of diseases associated with ribosome dysfunction, potentially improving patient outcomes.
How similar studies have performed: While the specific approach of this research is novel, there have been successful studies exploring ribosome biogenesis and its implications in various diseases.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Paralkar, Vikram R. — University of Pennsylvania
- Study coordinator: Paralkar, Vikram R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.