Understanding how RGS2 protein levels are controlled in the body
Posttranslational regulation of Regularo of G protein Signaling 2 (RGS2)
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-10927671
This study is looking at how a protein called RGS2, which is important for cell signaling and related to conditions like asthma and heart disease, is controlled in the body, with the goal of finding new ways to improve its function for better treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-10927671 on ClinicalTrials.gov |
What this research studies
This research investigates the regulation of RGS2, a protein that plays a crucial role in cell signaling related to various diseases, including asthma and heart conditions. The team aims to identify mechanisms that control the levels and activity of RGS2, focusing on how it is degraded and modified after being produced. By uncovering these regulatory processes, the research seeks to find new ways to enhance RGS2 function, which could lead to better treatments for conditions associated with low RGS2 levels.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from asthma, hypertension, or heart failure.
Not a fit: Patients with conditions unrelated to RGS2 regulation or those who do not have the aforementioned diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating asthma, hypertension, and heart failure.
How similar studies have performed: Previous research has shown that targeting similar regulatory mechanisms in other proteins has led to successful therapeutic advancements, suggesting potential for success in this area as well.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SJOGREN, BENITA JENNY — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: SJOGREN, BENITA JENNY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.