Understanding how RGS proteins control cell signaling
Official title: Spatiotemporal control of RGS signaling
Funded at University of Maine Orono · NIH-10974499 · Data updated 2026-11-12
This study is looking at how certain proteins help cells communicate and respond to signals, using yeast to learn more about how this might affect human health, especially in areas like cancer and heart disease.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maine Orono NIH-funded |
| Lab location | 1 site (Orono, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $432,422 |
| NIH project number | 1R15GM155864-01 |
| Project ID | NIH-10974499 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to cancer or cardiac diseases, as they may benefit from advancements in understanding cell signaling.
✕Less likely to help
Patients with unrelated health conditions or those not affected by cancer or cardiac diseases may not receive direct benefits from this research.
What this research studies
This research investigates the role of Regulators of G-protein Signaling (RGS) proteins in controlling cell communication and responses to external signals. By using advanced techniques like live cell imaging and yeast genetics, the team aims to uncover how RGS proteins interact with receptors and other cellular structures to regulate processes such as hormone signaling and immune function. The study focuses on understanding these mechanisms in yeast, which can provide insights applicable to human health, particularly in cancer and cardiac diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting cell signaling pathways in diseases like cancer and cardiac disorders.
How similar studies have gone: While the specific approach of this research is novel, similar studies have successfully advanced our understanding of cell signaling in other contexts.
Where this research is happening
-
University of Maine Orono
Orono, United States Active
Researchers
- Principal investigator: Kelley, Joshua Brian — University of Maine Orono
- Study coordinator: Kelley, Joshua Brian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.