Understanding how reward responses relate to depression in adolescents with autism

Reward responsivity and depression in autism spectrum disorder: A multimethod approach

NIH-funded research Children's Hospital of Los Angeles · NIH-10994165

This study is looking at how feeling rewarded—whether from social interactions or other activities—affects depression in teenagers with Autism Spectrum Disorder, and it hopes to find ways to help them feel better.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionChildren's Hospital of Los Angeles NIH-funded
Lab location1 site (Los Angeles, United States)
Project IDNIH-10994165 on NIH RePORTER

What this research studies

This research investigates the relationship between reward responsivity and depression in adolescents with Autism Spectrum Disorder (ASD). It aims to identify risk factors for depression by using both clinical assessments and objective measures like electroencephalograms (EEG). The study focuses on understanding how social and nonsocial rewards affect depression symptoms in this population, which may help in developing better interventions. By examining these factors, the research seeks to provide insights into the unique challenges faced by adolescents with ASD.

Who could benefit from this research

Good fit: Ideal candidates for this research are adolescents aged 12 to 21 who are diagnosed with Autism Spectrum Disorder and experiencing symptoms of depression.

Not a fit: Patients who do not have Autism Spectrum Disorder or who are outside the age range of 12 to 21 may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved understanding and treatment options for depression in adolescents with autism.

How similar studies have performed: While research on reward responsivity in neurotypical adolescents has shown promise, this specific approach in adolescents with autism is relatively novel and has not been extensively tested.

Where this research is happening

Los Angeles, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions adolescent with autism spectrum disorder
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.