Understanding how retroviruses integrate their genetic material into host cells
Official title: Determinants of Architecture on Retroviral Intasome Mechanics
Funded at Ohio State University · NIH-11057697 · Data updated 2026-11-12
This study is looking at how viruses like HIV insert their genetic material into our cells, which could help us find better ways to fight these infections and improve treatments for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | June 5, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $472,500 |
| NIH project number | 5R01GM150003-03 |
| Project ID | NIH-11057697 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV or other retroviral infections.
✕Less likely to help
Patients with non-retroviral infections or those not affected by viral diseases may not benefit from this research.
What this research studies
This research investigates the mechanics of how retroviruses, such as HIV, integrate their genetic material into the DNA of host cells. It focuses on the structure and behavior of a complex called the intasome, which is crucial for this integration process. By examining the different forms of the integrase enzyme and how they interact with viral DNA, the study aims to fill gaps in our understanding of retroviral behavior. This could lead to new insights into how to combat viral infections and improve treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients with HIV and other retroviral infections.
How similar studies have gone: Previous research has shown success in understanding retroviral integration mechanics, but this specific approach to studying intasome architecture is relatively novel.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Yoder, Kristine E — Ohio State University
- Study coordinator: Yoder, Kristine E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.