Understanding how retinoic acids affect fat metabolism in brain tumors
Delineating how retinoic acids regulate lipid metabolism in glioblastoma and their resistance mechanisms
This study is looking at how certain vitamins, called retinoic acids, might help us understand and improve treatments for glioblastoma, a tough type of brain tumor, by seeing how they affect fat production in the tumor cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10867339 on NIH RePORTER |
What this research studies
This research investigates the role of retinoic acids in regulating lipid metabolism in glioblastoma, a highly aggressive brain tumor. The study aims to uncover how these acids can influence the expression of key proteins involved in fat synthesis, which may contribute to the tumor's ability to resist treatments. By examining the effects of all-trans retinoic acid and 13-cis-retinoic acid on glioblastoma cells, the research seeks to identify potential therapeutic strategies to overcome treatment resistance. Patients may benefit from insights that could lead to improved treatment options for glioblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with glioblastoma who are seeking new treatment options.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that enhance the effectiveness of therapies for glioblastoma patients.
How similar studies have performed: Previous research has shown that targeting lipid metabolism in cancer cells can be effective, suggesting potential for success in this approach.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Guo, Deliang — Ohio State University
- Study coordinator: Guo, Deliang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.