Understanding how retinoblastoma, a childhood eye cancer, develops using 3D models of retinal cells.
Modeling Retinoblastoma Initiation Using 3D-Retinal Organoids
This study is looking at how retinoblastoma, a rare eye cancer in kids, starts and grows by using special lab-created eye tissues from children with genetic changes, which could help find better ways to treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10834132 on NIH RePORTER |
What this research studies
This research investigates the initiation and progression of retinoblastoma, a rare cancer affecting the retina in children. By creating 3D retinal organoids from patients with genetic mutations, the team aims to explore critical questions about how this cancer develops and evolves. The study will utilize advanced techniques in stem cell biology and computational analysis to uncover the mechanisms behind tumor formation and progression, which could lead to better treatment strategies. This innovative approach allows researchers to study the disease in a controlled environment, overcoming limitations of traditional methods.
Who could benefit from this research
Good fit: Ideal candidates for this research include children with germline RB1 mutations or those diagnosed with retinoblastoma.
Not a fit: Patients without retinoblastoma or those who do not carry RB1 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for children diagnosed with retinoblastoma.
How similar studies have performed: Previous research has shown success in using organoid models for studying various cancers, indicating potential for this novel approach in retinoblastoma.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Dyer, Michael a — St. Jude Children's Research Hospital
- Study coordinator: Dyer, Michael a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.