Understanding how retinal circuitry changes in diseases like Alzheimer's and macular degeneration
Retinal Circuitry
This study is looking at how the connections in the retina change when people have eye diseases like age-related macular degeneration and Alzheimer's, and it aims to help find new treatments for these conditions by comparing the retina in different animals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11048890 on NIH RePORTER |
What this research studies
This research investigates the intricate wiring of the retina and how it is altered in various diseases, including age-related macular degeneration and Alzheimer's disease. By creating detailed maps of retinal connections, known as connectomes, the study aims to provide insights into the structural changes that occur in retinal diseases. The research involves comparing the retinal circuitry across different species, including mice and non-human primates, to better understand the disease mechanisms. This work could lead to the development of new therapeutic strategies for retinal disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with age-related macular degeneration, achromatopsia, or Alzheimer's disease.
Not a fit: Patients with retinal conditions unrelated to the diseases being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from retinal diseases and related conditions.
How similar studies have performed: Previous research has shown promise in understanding retinal circuitry and its implications for disease, making this approach a continuation of successful methodologies.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Jones, Bryan William — University of Utah
- Study coordinator: Jones, Bryan William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.