Understanding how retinal changes affect vision loss
Official title: Molecular and physiological mechanisms of inner retinal remodeling
Funded at University of Rochester · NIH-11049476 · Data updated 2026-11-12
This study is looking at how the retina changes when it starts to break down, which can cause low vision or blindness, and it aims to find ways to help improve vision by targeting certain cells that are misbehaving in the eye.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $437,310 |
| NIH project number | 1R01EY036020-01A1 |
| Project ID | NIH-11049476 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing vision loss due to retinal degeneration, particularly those with conditions affecting retinal ganglion cells.
✕Less likely to help
Patients with vision loss not related to retinal degeneration or those with advanced stages of degeneration where no intervention is possible may not benefit from this research.
What this research studies
This research investigates the biological processes that occur in the retina during degeneration, which leads to low vision and blindness. It focuses on the remodeling of inner retinal neurons, particularly how retinal ganglion cells become hyperactive and disrupt visual signals. By studying these mechanisms, the research aims to identify potential interventions that could improve visual function, even after significant retinal damage. The approach includes manipulating specific receptors involved in this remodeling process to enhance visual acuity and contrast sensitivity.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that restore vision or improve visual function in individuals with retinal degeneration.
How similar studies have gone: Previous research has shown promise in understanding retinal remodeling and its effects on vision, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Telias, Michael — University of Rochester
- Study coordinator: Telias, Michael
Related research
Other NIH-funded projects on the same topics.
-
Rapid automated breast lump diagnosis without a radiologist or sonographer
A new AI-powered ultrasound tool helps determine if a palpable breast lump is likely benign or malignant, using a simplified technique that can be used by people with minimal ultrasound training.
-
ML-ROVER: Reducing Unneeded Lab Tests in Kids with AI
Aims to use machine learning to cut unnecessary blood tests in children in intensive care, helping avoid anemia and improve care quality.
-
Aggressive fever-reducing therapy to protect the brains of children with CNS malaria
A study planned for children with CNS malaria will test whether aggressive fever-reducing treatment can lower death and brain-related problems.
-
Aggressive fever-reducing therapy to protect brains in children with CNS malaria
A plan to test whether giving strong fever-reducing medications to children with central nervous system malaria can lower death and brain injury.
-
Aggressive fever-fighting treatment to protect the brain in kids with CNS malaria
A plan to test whether giving strong fever-reducing treatment alongside standard care can lower death and brain injury in children with CNS malaria.
-
Aggressive fever-reducing treatment to protect brains in kids with CNS malaria
A plan to test whether giving strong fever-reducing medicine alongside standard malaria treatment can lower deaths and brain injuries in children with CNS malaria.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.