Understanding how retinal changes affect vision loss
Molecular and physiological mechanisms of inner retinal remodeling
['FUNDING_R01'] · UNIVERSITY OF ROCHESTER · NIH-11049476
This study is looking at how the retina changes when it starts to break down, which can cause low vision or blindness, and it aims to find ways to help improve vision by targeting certain cells that are misbehaving in the eye.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11049476 on ClinicalTrials.gov |
What this research studies
This research investigates the biological processes that occur in the retina during degeneration, which leads to low vision and blindness. It focuses on the remodeling of inner retinal neurons, particularly how retinal ganglion cells become hyperactive and disrupt visual signals. By studying these mechanisms, the research aims to identify potential interventions that could improve visual function, even after significant retinal damage. The approach includes manipulating specific receptors involved in this remodeling process to enhance visual acuity and contrast sensitivity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing vision loss due to retinal degeneration, particularly those with conditions affecting retinal ganglion cells.
Not a fit: Patients with vision loss not related to retinal degeneration or those with advanced stages of degeneration where no intervention is possible may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that restore vision or improve visual function in individuals with retinal degeneration.
How similar studies have performed: Previous research has shown promise in understanding retinal remodeling and its effects on vision, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TELIAS, MICHAEL — UNIVERSITY OF ROCHESTER
- Study coordinator: TELIAS, MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.