Understanding how retinal cells respond to stress and injury
Official title: The Role of Müller Glia in Acute and Chronic Response to Stress, Injury, and Disease in the Retina
Funded at St. Jude Children's Research Hospital · NIH-11071173 · Data updated 2026-11-12
This study is looking at how certain cells in the eye respond to stress and injury, which can help us understand inflammation related to eye diseases like age-related macular degeneration, so we can learn more about how these processes affect vision loss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $606,034 |
| NIH project number | 1R01EY037117-01 |
| Project ID | NIH-11071173 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing retinal diseases such as age-related macular degeneration or those with acute retinal injuries.
✕Less likely to help
Patients with retinal conditions unrelated to inflammation or those without any retinal disease may not benefit from this research.
What this research studies
This research investigates the role of Müller glia and other retinal cells in the inflammatory response to stress, injury, and disease in the retina. It focuses on both acute inflammation, often linked to infections, and chronic inflammation associated with retinal diseases like age-related macular degeneration. By examining how different cell types interact during these processes, the study aims to fill gaps in knowledge about their roles in vision loss. The approach includes detailed profiling of cellular responses in both human and mouse retinae.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect vision by targeting inflammatory processes in the retina.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammation in retinal diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Dyer, Michael a — St. Jude Children's Research Hospital
- Study coordinator: Dyer, Michael a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.