Understanding how retinal cells interact during neurodegeneration and inflammation
Establishing a human cellular model of retinal ganglion cell compartmentalization in neurodegeneration and neuroinflammation
This study is looking at how certain brain cells interact and affect each other when vision is lost, especially in conditions like glaucoma, to help find new ways to protect your eyesight.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10927370 on NIH RePORTER |
What this research studies
This research investigates the interactions between retinal ganglion cells (RGCs) and glial cells, such as astrocytes and microglia, in the context of neurodegeneration and neuroinflammation. By developing a human cellular model, the research aims to replicate the conditions that lead to vision loss, particularly in diseases like glaucoma. The approach focuses on understanding how these cells support each other and how their dysfunction contributes to RGC degeneration. This could provide insights into the mechanisms of vision loss and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing vision loss or at risk for conditions like glaucoma and other neurodegenerative disorders affecting the retina.
Not a fit: Patients with vision loss due to non-neurodegenerative causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating vision loss associated with neurodegenerative diseases.
How similar studies have performed: Previous research has shown success in using cellular models to study neurodegeneration, but this specific approach focusing on human retinal cells is relatively novel.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Meyer, Jason Stephen — Indiana University Indianapolis
- Study coordinator: Meyer, Jason Stephen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.