Understanding how retinal cells die after blood flow loss
Molecular mechanisms of programmed necrosis in the ischemic retina
This study is looking at how certain cells in the eye die after a lack of blood flow, which can cause vision problems, and aims to find ways to protect these important cells so that new treatments can help people with eye diseases related to blood flow issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10887487 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind cell death in the retina following ischemia-reperfusion injury, a condition that can lead to vision loss. The focus is on retinal ganglion cells, which are crucial for vision and can undergo programmed cell death known as necroptosis. By identifying the signaling pathways that regulate this process, the research aims to uncover potential therapeutic targets to protect these cells from damage. Patients may benefit from insights that could lead to new treatments for retinal diseases caused by blood flow issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing retinal ischemia or related visual impairments.
Not a fit: Patients with non-ischemic retinal conditions or those whose vision loss is unrelated to retinal cell death may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that protect retinal cells and improve vision in patients suffering from ischemic conditions.
How similar studies have performed: Previous research has shown that understanding programmed cell death mechanisms can lead to significant advancements in treating retinal diseases, indicating a promising avenue for this investigation.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Ivanov, Dmitry V — University of Miami School of Medicine
- Study coordinator: Ivanov, Dmitry V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.