Understanding how retinal cells connect to process visual signals
Mechanisms underlying CD3 guided assembly of retinal circuits
This study is looking at how certain cells in the eye work together to help us see, and it's trying to find out why some of these connections go wrong, which can lead to serious eye problems like glaucoma; the goal is to discover new ways to help improve vision for people affected by these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10653909 on NIH RePORTER |
What this research studies
This research investigates the intricate connections between bipolar cells and retinal ganglion cells in the retina, which are crucial for processing visual information. By exploring the mechanisms that guide these cells to wire together correctly, the study aims to uncover the reasons behind defects that lead to severe eye diseases like glaucoma. The researchers are employing innovative techniques to label and analyze these connections, which could pave the way for new therapies to restore vision. The findings may help clarify how different types of retinal cells interact and function in healthy and diseased states.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old who are experiencing or at risk for retinal diseases, particularly glaucoma.
Not a fit: Patients with retinal conditions unrelated to bipolar or ganglion cell wiring may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for retinal diseases, potentially restoring vision for patients affected by conditions like glaucoma.
How similar studies have performed: While the specific approach of this research is novel, similar studies have shown promise in understanding neuronal wiring and its implications for treating retinal diseases.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Tian, Ning — University of Utah
- Study coordinator: Tian, Ning
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.