Understanding how respiratory viruses affect immune response in lung cells
Silencer-enhancer transition dysregulates interleukin-6 in mucosal epithelial cell plasticity
['FUNDING_R21'] · UNIVERSITY OF TEXAS MED BR GALVESTON · NIH-10988788
This study is looking at how a substance called IL-6 affects lung cells when they fight off viruses like the flu, with the hope of finding ways to better manage inflammation and help people recover faster from respiratory infections.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS MED BR GALVESTON (nih funded) |
| Locations | 1 site (GALVESTON, UNITED STATES) |
| Trial ID | NIH-10988788 on ClinicalTrials.gov |
What this research studies
This research investigates the role of interleukin-6 (IL-6) in the immune response of lung epithelial cells during respiratory viral infections. By using advanced sequencing techniques, the study aims to uncover how IL-6 production is regulated in these cells, particularly when they undergo changes that affect their function. The goal is to identify the mechanisms that control IL-6 levels, which could help in managing inflammation and improving antiviral responses in patients. This research focuses on understanding the genetic factors that influence how lung cells respond to viruses like influenza and rhinovirus.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults and older patients who are at risk for severe respiratory viral infections.
Not a fit: Patients with non-respiratory viral infections or those without significant lung issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for respiratory viral infections by better regulating immune responses.
How similar studies have performed: Other research has shown promising results in understanding immune responses to respiratory viruses, indicating that this approach has potential for success.
Where this research is happening
GALVESTON, UNITED STATES
- UNIVERSITY OF TEXAS MED BR GALVESTON — GALVESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, JUN — UNIVERSITY OF TEXAS MED BR GALVESTON
- Study coordinator: YANG, JUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.