Understanding how respiratory viruses affect asthma in children
Official title: Systemic and intercellular gene networks underlying RV-induced airways disease
Funded at University of Arizona · NIH-10851949 · Data updated 2026-11-12
This study is looking at how viral infections can cause wheezing in kids and increase their chances of getting asthma, by checking how their immune systems react to these viruses, so we can better understand why some children are more at risk than others.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | June 1, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $153,500 |
| NIH project number | 5R21AI176305-02 |
| Project ID | NIH-10851949 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 12 to 20 years who experience wheezing and have allergies.
✕Less likely to help
Patients who do not have a history of wheezing or allergies may not benefit from this research.
What this research studies
This research investigates how respiratory viral infections lead to wheezing illnesses in children and their increased risk of developing asthma. It focuses on understanding the immune responses in children with and without wheezing and allergies by analyzing blood-derived immune cells in the presence of viruses. The study employs advanced molecular profiling technologies to examine these immune responses at a single-cell level, comparing different groups of children to uncover the underlying mechanisms of susceptibility to asthma.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for asthma in children, particularly those with a history of wheezing and allergies.
How similar studies have gone: Previous research has shown that understanding immune responses to respiratory viruses can lead to significant advancements in asthma treatment, indicating a promising approach in this area.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Bosco, Anthony — University of Arizona
- Study coordinator: Bosco, Anthony
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.