Understanding how resident memory T cells work in the body
Resident Memory T Cells
This study is looking at special immune cells that help protect us from infections and fight tumors, and it's for anyone interested in how we can improve vaccines and cancer treatments by better understanding these cells and how they work in our bodies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11129337 on NIH RePORTER |
What this research studies
This research investigates resident memory T cells (Trm), which play a crucial role in protecting against infections and controlling tumors. The project aims to develop new assays to understand how these cells function in tissues and how they can be manipulated for better vaccine and cancer therapy development. By using advanced gene editing techniques and a specialized mouse model, the researchers will explore the signals that influence Trm development and their responses during infections and cancer. The findings could lead to innovative strategies for enhancing immune protection or treating diseases driven by unwanted immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions related to infections, cancer, or autoimmune diseases who may benefit from improved immune therapies.
Not a fit: Patients with non-immune related conditions or those who do not have any immune system involvement may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance immune protection against infections and cancer while also providing treatments for autoimmune and inflammatory diseases.
How similar studies have performed: Previous research has shown promise in manipulating immune cells for therapeutic purposes, indicating that this approach could yield significant advancements.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Masopust, David — University of Minnesota
- Study coordinator: Masopust, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.