Understanding how repetitive DNA sequences affect genome stability and variation
Repetitive sequences drive genome variation and plasticity
This study is looking at how certain repetitive DNA sequences help keep our genes stable over time and how problems with these sequences might lead to diseases like cancer, so it's for anyone interested in understanding the genetic causes of health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-11019226 on NIH RePORTER |
What this research studies
This research investigates the role of repetitive DNA sequences in maintaining the stability of mammalian genomes across generations. It focuses on how disruptions in these sequences can lead to diseases, including cancer, by causing genomic instability. The study employs advanced molecular genomics and computational biology techniques to analyze the effects of transposable elements and structural variations in both human and mouse genomes. By understanding these mechanisms, the research aims to shed light on the genetic factors that contribute to various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic disorders or cancers that may be linked to genomic instability.
Not a fit: Patients with stable genomes and no history of genetic disorders or cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic causes of diseases, potentially improving diagnosis and treatment options for patients.
How similar studies have performed: Other research has shown success in understanding genomic instability through similar approaches, indicating a promising avenue for further exploration.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Beck, Christine R — University of Connecticut Sch of Med/dnt
- Study coordinator: Beck, Christine R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.