Understanding how repetitive DNA sequences affect cell function and stability
Repetitive sequences causing genomic instability and cell dysfunction
['FUNDING_OTHER'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11004962
This study is looking at how certain repeated DNA and RNA sequences can cause problems in our cells, which might lead to diseases, and it’s especially focused on understanding the role of the BRCA1 protein in keeping our genes healthy.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11004962 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which repetitive DNA and RNA sequences can lead to genomic instability and cell dysfunction. It focuses on how these sequences can interfere with essential cellular processes like DNA replication and protein translation, potentially causing severe consequences such as mutations and diseases. The study aims to explore the role of the BRCA1 protein in maintaining genomic integrity and how variations in its expression might affect cellular health. By identifying the errors that occur during the processing of these sequences, the research seeks to uncover new insights into the prevention of diseases linked to genomic instability.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of breast or ovarian cancer, particularly those with known mutations in the BRCA1 gene.
Not a fit: Patients without any genetic predisposition to genomic instability or those not affected by related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for diseases caused by genomic instability, including certain cancers and neurological disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of BRCA1 in genomic stability, indicating that this approach has potential for significant advancements.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GERHARDT, JEANNINE — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: GERHARDT, JEANNINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer 1 Gene, Breast Cancer 1 Gene Product, Breast Cancer Type 1 Susceptibility Gene, Breast Cancer Type 1 Susceptibility Protein, Breast-Ovarian Cancer Protein