Understanding how repetitive DNA elements affect cancer and cell growth
Chromatin of repetitive elements
['FUNDING_R01'] · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · NIH-10832996
This study is looking at how certain DNA pieces in our cells can cause problems like cancer and how our bodies try to keep them in check, which could help us find new ways to treat cancer in the future.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-10832996 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which transposable and repetitive DNA elements are recognized and silenced in the genome, which is crucial for maintaining genome integrity. By employing a combination of genetics, molecular biology, biochemistry, and advanced imaging techniques like cryo-electron microscopy, the study aims to uncover how these elements contribute to cancer formation and cellular processes. The focus is particularly on ribosomal DNA, which plays a key role in ribosome assembly and cellular function. Insights gained from this research could lead to a better understanding of cancer biology and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of cancer or those diagnosed with malignancies related to genomic instability.
Not a fit: Patients with non-genetic forms of cancer or those whose malignancies are not influenced by genomic elements may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new insights into cancer prevention and treatment by identifying how genomic integrity is maintained.
How similar studies have performed: Previous research has shown success in understanding the role of transposable elements in cancer, but this specific approach to studying ribosomal DNA and chromatin regulation is relatively novel.
Where this research is happening
MEMPHIS, UNITED STATES
- ST. JUDE CHILDREN'S RESEARCH HOSPITAL — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HALIC, MARIO — ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Study coordinator: HALIC, MARIO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer