Understanding how repeated stretching affects heart stiffness in patients with chronic coronary artery disease.
Official title: Repetitive Stretch-Induced Myocardial Stiffening in Chronic Coronary Artery Disease
Funded at VA Western New York Healthcare System · NIH-11109487 · Data updated 2026-11-12
This study is looking at how heart stiffness affects Veterans with heart failure and preserved ejection fraction, especially how stretching of the heart muscle from long-term heart issues can make breathing harder, with the goal of finding new ways to help improve their symptoms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Western New York Healthcare System NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01BX006124-03 |
| Project ID | NIH-11109487 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Veterans suffering from heart failure with preserved ejection fraction and chronic coronary artery disease.
✕Less likely to help
Patients without heart failure or those with other unrelated cardiovascular conditions may not benefit from this research.
What this research studies
This research investigates the mechanisms behind heart stiffness in patients with heart failure and preserved ejection fraction (HFpEF), particularly among Veterans. It focuses on how repetitive stretching of the heart muscle, due to chronic coronary artery disease, leads to changes in the heart's structure that can worsen symptoms like breathlessness. By studying these changes in detail, the research aims to uncover potential new treatment strategies that could improve patient outcomes. The approach includes using animal models to simulate human heart conditions and analyze the resulting cardiac tissue changes.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function and reduce symptoms for patients with HFpEF.
How similar studies have gone: Previous research has shown promising results in understanding heart stiffness mechanisms, but this specific approach is relatively novel.
Where this research is happening
-
VA Western New York Healthcare System
Buffalo, United States Active
Researchers
- Principal investigator: Weil, Brian Raymond — VA Western New York Healthcare System
- Study coordinator: Weil, Brian Raymond
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.