Understanding how repeated opioid use affects breathing control
Mechanisms of repeated opioid use dependent remodeling in respiratory control
This study looks at how using opioids like fentanyl over and over affects breathing, especially for people with substance use disorders, to help find better ways to prevent overdoses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11085150 on NIH RePORTER |
What this research studies
This research investigates the effects of repeated opioid use on respiratory control, particularly focusing on individuals with substance use disorders. It aims to fill the knowledge gap regarding how repeated exposure to opioids alters breathing patterns and increases the risk of overdose. By developing a model that simulates repeated fentanyl use, the study examines the context-dependent mechanisms that influence tolerance to respiratory depression. The findings could lead to better strategies for preventing opioid overdoses in vulnerable populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of repeated opioid use or substance use disorders.
Not a fit: Patients who have never used opioids or those with acute, non-chronic pain conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for opioid overdose, particularly for individuals with a history of opioid use.
How similar studies have performed: While there is existing knowledge about opioid effects on breathing, this specific approach to understanding context-dependent tolerance is novel and has not been extensively tested.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Garcia, Alfredo J — University of Chicago
- Study coordinator: Garcia, Alfredo J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.