Understanding how reoviruses interact with cell membranes during infection
Real-time single particle analysis of reovirus-membrane interactions that drive infection
['FUNDING_R21'] · TRUSTEES OF INDIANA UNIVERSITY · NIH-10624933
This study is looking at how reoviruses get into cells to spread their genetic material, using a new method to see this process in real-time, which could help us understand how these viruses work and find new ways to treat infections.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TRUSTEES OF INDIANA UNIVERSITY (nih funded) |
| Locations | 1 site (BLOOMINGTON, UNITED STATES) |
| Trial ID | NIH-10624933 on ClinicalTrials.gov |
What this research studies
This research investigates how reoviruses penetrate host cell membranes to deliver their genetic material, which is crucial for their replication. By developing a new method to analyze these interactions in real-time at a single particle level, the study aims to uncover the mechanisms by which reoviruses, specifically through a protein called myr-µ1N, facilitate their entry into cells. This approach will help clarify the transient events that occur during viral infection, which are currently poorly understood. The findings could lead to new insights into viral behavior and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are infected with reoviruses or are at risk of such infections.
Not a fit: Patients who do not have reovirus infections or are not at risk for such infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or treating infections caused by reoviruses and potentially other similar viruses.
How similar studies have performed: While the specific approach of real-time single particle analysis is novel, similar studies have successfully elucidated viral entry mechanisms in other contexts.
Where this research is happening
BLOOMINGTON, UNITED STATES
- TRUSTEES OF INDIANA UNIVERSITY — BLOOMINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DANTHI, PRANAV — TRUSTEES OF INDIANA UNIVERSITY
- Study coordinator: DANTHI, PRANAV
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Infection