Understanding how reoviruses change their genetic makeup
Effects of Reoviridae assembly and transmission processes on viral genetic diversity
This research explores how certain viruses, including those that cause human and animal illnesses, change their genetic makeup to infect and adapt.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11094843 on NIH RePORTER |
What this research studies
We are looking into how viruses called Reoviridae, which can cause sickness in people and animals, manage their genetic material. These viruses have a unique way of packaging their genes, and this process affects how they spread and how our bodies respond to vaccines. By understanding how these viruses create genetic diversity, we hope to learn more about how they infect cells and adapt over time. We will use a specific type of reovirus and study its genetic segments to find out what controls its packaging and assortment.
Who could benefit from this research
Good fit: This foundational laboratory research does not involve direct patient participation, but future clinical applications could benefit individuals affected by Reoviridae infections.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not find direct benefit from this basic science project.
Why it matters
Potential benefit: This work could lead to a better understanding of how these viruses cause disease and help in developing more effective vaccines or antiviral treatments in the future.
How similar studies have performed: This project builds upon established models for reovirus, suggesting a foundation of prior successful research in this area.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Ogden, Kristen M — Vanderbilt University Medical Center
- Study coordinator: Ogden, Kristen M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.