Understanding how Reoviridae viruses evolve and transmit genetic diversity
Effects of Reoviridae assembly and transmission processes on viral genetic diversity
This study is looking at how certain viruses, which can make both people and animals sick, put together their genetic material and spread, with the goal of finding ways to create better vaccines and treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10868569 on NIH RePORTER |
What this research studies
This research investigates the assembly and transmission processes of Reoviridae viruses, which are significant pathogens for both humans and animals. By examining how these viruses package their genetic material and promote genetic diversity, the research aims to uncover mechanisms that influence their ability to infect and adapt. Using advanced sequencing techniques and established animal models, the study will identify key RNA elements that facilitate the virus's genetic assortment and transmission. This knowledge could lead to improved strategies for vaccine development and antiviral therapies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals affected by diseases caused by Reoviridae viruses, such as certain viral infections in humans and animals.
Not a fit: Patients with conditions unrelated to Reoviridae viruses or those not affected by viral infections may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of viral evolution and lead to better vaccines and treatments for diseases caused by Reoviridae viruses.
How similar studies have performed: Other research has shown success in understanding viral genetic diversity and its implications for vaccine responses, making this approach both relevant and promising.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Ogden, Kristen M — Vanderbilt University Medical Center
- Study coordinator: Ogden, Kristen M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.