Understanding how renin cells function and adapt in the body
Official title: The reninness score: integrative analysis of multi-omic data to define renin cell identity
Funded at University of Virginia · NIH-11070925 · Data updated 2026-11-12
This study is looking at special cells in your body that help control blood pressure and fluid balance, to understand how they change their roles when your body needs them to, which could lead to better treatments for kidney health and blood pressure issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $40,196 |
| NIH project number | 1F31DK139601-01A1 |
| Project ID | NIH-11070925 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with conditions affecting blood pressure regulation or kidney function.
✕Less likely to help
Patients with no kidney-related issues or those outside the age range of 21+ years may not benefit from this research.
What this research studies
This research investigates the role of renin cells, which are essential for regulating blood pressure and maintaining fluid balance in the body. By analyzing multi-omic data, the study aims to uncover the mechanisms that control the identity and function of these cells, particularly how they can switch their roles in response to physiological changes. Patients may benefit from insights gained into how these cells contribute to kidney health and blood pressure regulation, potentially leading to new treatment strategies. The research employs advanced techniques like ATAC-seq and RNA-seq to explore the genetic and epigenetic factors influencing renin cell behavior.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of conditions related to blood pressure and kidney function.
How similar studies have gone: While the specific approach of integrating multi-omic data for renin cell analysis is novel, similar studies have shown success in understanding other cell types and their regulatory mechanisms.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Xue, Bingjie — University of Virginia
- Study coordinator: Xue, Bingjie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.