Understanding how regulatory T cells adapt during inflammation
Official title: Mechanisms of regulatory T cell adaptation to inflammation
Funded at Mayo Clinic Rochester · NIH-11101316 · Data updated 2026-11-12
This study is looking at how certain immune cells called regulatory T cells respond to inflammation, with the goal of finding new ways to help these cells work better and improve the success of organ transplants for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | June 3, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $182,520 |
| NIH project number | 5K08AI182489-02 |
| Project ID | NIH-11101316 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals undergoing or considering organ transplantation who may benefit from enhanced immune regulation.
✕Less likely to help
Patients with conditions unrelated to transplantation or those not experiencing inflammation may not receive benefits from this research.
What this research studies
This research investigates the behavior of regulatory T cells (Tregs) in response to inflammation, aiming to develop new therapies that enhance Treg function for better outcomes in transplantation. The project involves a multidisciplinary approach, utilizing expertise in Treg biology, immunometabolism, and clinical trials to explore how inflammatory signals affect Tregs. By understanding these mechanisms, the research seeks to create innovative treatments that could improve transplant success and reduce rejection rates.
Why it matters
Potential benefit: If successful, this research could lead to advanced therapies that improve transplant outcomes and reduce the risk of rejection for patients.
How similar studies have gone: Previous research has shown promise in enhancing Treg function in other contexts, suggesting that this approach could yield significant advancements in transplantation.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Skartsis, Nikolaos — Mayo Clinic Rochester
- Study coordinator: Skartsis, Nikolaos
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.