Understanding how regulatory DNA controls gene expression
Official title: Multiscale genomic decryption of regulatory DNA
Funded at University of California, San Diego · NIH-10624086 · Data updated 2026-11-12
This study is looking at how certain parts of our DNA work together with proteins to control how genes are turned on and off, which is important for how our cells grow and respond to different signals.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $387,585 |
| NIH project number | 1R35GM149520-01 |
| Project ID | NIH-10624086 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or conditions linked to gene expression abnormalities.
✕Less likely to help
Patients with conditions unrelated to genetic regulation or those not affected by gene expression issues may not benefit from this research.
What this research studies
This research investigates the complex interactions of regulatory DNA and transcription factors that dictate how genes are expressed in response to various developmental signals. By employing both experimental and computational methods, the team aims to decode the organization and function of regulatory elements in the genome. This work will enhance our understanding of how multiple regulatory sites work together to influence gene activity, which is crucial for proper cellular function and response to stimuli.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for diagnosing and treating genetic disorders by providing insights into gene regulation.
How similar studies have gone: Previous research has shown promising results in understanding gene regulation through similar experimental and computational approaches.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Benner, Christopher W — University of California, San Diego
- Study coordinator: Benner, Christopher W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.