Understanding how redox regulation affects stroke in African Americans
Official title: Cerebral Vascular Redox Regulation in Stroke
Funded at University of Pittsburgh at Pittsburgh · NIH-11098718 · Data updated 2026-11-12
This study is looking at why African Americans might have more strokes and different recovery experiences compared to others, focusing on a specific gene that could make them more vulnerable, and it aims to find better treatments for those affected by strokes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | July 15, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $537,392 |
| NIH project number | 5R01NS129613-03 |
| Project ID | NIH-11098718 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are African American adults who have experienced ischemic stroke or are at high risk for stroke.
✕Less likely to help
Patients who are not African American or those who have not experienced ischemic stroke may not benefit from this research.
What this research studies
This research investigates the differences in stroke prevalence and outcomes among African Americans compared to other populations, focusing on the role of oxidative stress and blood flow regulation in ischemic stroke. The study aims to identify genetic factors, specifically a variant in the CYB5R3 gene, that may contribute to increased vulnerability to stroke in this population. By using a novel mouse model, researchers will explore how this genetic variant affects cerebral vascular function and stroke recovery. The ultimate goal is to improve treatment strategies for African Americans who suffer from ischemic stroke.
Why it matters
Potential benefit: If successful, this research could lead to better-targeted therapies and improved recovery outcomes for African Americans affected by ischemic stroke.
How similar studies have gone: Other research has shown promising results in understanding genetic factors affecting stroke outcomes, but this specific focus on the CYB5R3 variant in African Americans is relatively novel.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Straub, Adam Carl — University of Pittsburgh at Pittsburgh
- Study coordinator: Straub, Adam Carl
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.