Understanding how red blood cells help malaria parasites invade the body
Elucidating the functions of red blood cell factors in malaria parasite invasion
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-10874747
This study is looking at how malaria parasites get into red blood cells and cause illness, using special technology to change human blood cells, with the goal of finding new ways to treat malaria, especially for kids and pregnant women who are at higher risk.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10874747 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific factors in red blood cells that allow malaria parasites to invade and cause disease. Using advanced CRISPR-Cas9 technology, the team will create modified human blood cells to study how these factors interact with the malaria parasite Plasmodium falciparum. By identifying the mechanisms behind this invasion, the research aims to uncover new therapeutic targets that could lead to better treatments for malaria, especially in vulnerable populations like children and pregnant women.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old and individuals at risk of severe malaria, particularly those in regions where malaria is endemic.
Not a fit: Patients who are not affected by malaria or who do not have any risk factors for malaria infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments or preventive measures against malaria, significantly reducing morbidity and mortality rates.
How similar studies have performed: Other research has successfully utilized CRISPR technology to explore genetic factors in disease, suggesting that this approach could yield valuable insights into malaria as well.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EGAN, ELIZABETH S. — STANFORD UNIVERSITY
- Study coordinator: EGAN, ELIZABETH S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus