Understanding How Red Blood Cells and Hemoglobin Are Made
Transcriptional Control of Hemoglobin Synthesis and Erythrocyte Development
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11112291
This research explores how our bodies create red blood cells and the vital protein hemoglobin, which carries oxygen.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11112291 on ClinicalTrials.gov |
What this research studies
Our bodies constantly make new red blood cells and hemoglobin, the protein that carries oxygen. This project looks closely at the genetic instructions, specifically 'GATA factors,' that guide this process. We are learning how these factors tell young cells to become mature red blood cells and how a molecule called 'heme' helps control this development. Understanding these steps is key to knowing why some people have problems making healthy red blood cells.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to help those with conditions affecting red blood cell production or hemoglobin synthesis.
Not a fit: Individuals without conditions related to red blood cell or hemoglobin production would not see direct benefits from this particular research.
Why it matters
Potential benefit: This work could lead to new ways to understand and treat conditions where the body struggles to make enough healthy red blood cells or hemoglobin.
How similar studies have performed: This project builds upon previous discoveries about how genetic factors control red blood cell development, while also exploring new, unanswered questions in the field.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRESNICK, EMERY H. — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: BRESNICK, EMERY H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.