Understanding how red blood cell progenitors can renew themselves
Official title: Erythroid Self-Renewal
Funded at University of Rochester · NIH-10823927 · Data updated 2026-11-12
This study is looking at how certain cells in your body that make red blood cells can keep making more of themselves, which could help improve blood transfusions and treatments for anemia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $677,600 |
| NIH project number | 1R01HL172500-01 |
| Project ID | NIH-10823927 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include individuals with anemia or conditions requiring blood transfusions.
✕Less likely to help
Patients with stable blood conditions or those not requiring blood products may not receive direct benefits from this research.
What this research studies
This research investigates the self-renewal process of erythroid progenitor cells, which are crucial for producing red blood cells in the body. By studying these cells both in laboratory settings and in living organisms, the researchers aim to uncover the mechanisms that allow these progenitors to replicate indefinitely. The project focuses on specific genes and proteins that influence this self-renewal process, potentially leading to improved methods for generating red blood cells for transfusions and treating anemia. Patients may benefit from advancements in blood production techniques that arise from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for anemia and improved blood transfusion methods.
How similar studies have gone: Previous research has shown promising results in understanding cell self-renewal, suggesting potential for success in this area as well.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Palis, James — University of Rochester
- Study coordinator: Palis, James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.