Understanding how red blood cell immune responses lead to complications in transfusions
Examining the Mechanisms of RBC Alloimmunization Hyperresponders
This study is looking at how the immune system reacts when people receive blood transfusions, especially why some patients develop antibodies that make it hard to find matching blood later, and it's aimed at helping those who need regular transfusions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10912657 on NIH RePORTER |
What this research studies
This research investigates the immune mechanisms behind red blood cell (RBC) alloimmunization, which occurs when a patient's immune system produces antibodies against transfused RBCs. The study aims to identify factors that increase the likelihood of developing multiple alloantibodies after transfusions, making it difficult to find compatible blood for patients. By examining the role of CD4 T cells and B cells in these immune responses, the research seeks to uncover ways to prevent complications in transfusion-dependent individuals. The approach includes analyzing immune events during initial alloimmunization and their effects on subsequent transfusions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are transfusion-dependent and have developed multiple alloantibodies against different RBC antigens.
Not a fit: Patients who do not require blood transfusions or have not experienced alloimmunization may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing transfusion-dependent patients, reducing complications related to incompatible blood transfusions.
How similar studies have performed: Previous research has shown promising results in understanding immune responses related to blood transfusions, indicating that this area of study has potential for significant advancements.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Arthur, Connie M — Brigham and Women's Hospital
- Study coordinator: Arthur, Connie M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.