Understanding how recycling endosomes control cell membranes in diabetes biology
Official title: Molecular regulation of endosome fission during endocytic recycling
Funded at Rutgers, the State Univ of N.j. · NIH-11384139 · Data updated 2026-11-12
Aims to uncover how recycling endosomes regulate membrane components in cells, which could shed light on mechanisms relevant to adult-onset diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project start | February 1, 2020 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $347,288 |
| NIH project number | 5R01GM135326-07 |
| Project ID | NIH-11384139 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with or at risk for adult-onset diabetes may benefit from insights derived from this basic cell biology research.
✕Less likely to help
Healthy individuals without diabetes may not directly benefit from the research.
What this research studies
This project uses the small worm model C. elegans to study how recycling endosomes form and function in a living organism, then tests what is learned in mammalian cells. By focusing on intestine cells, researchers hope to reveal key steps that control how proteins and lipids are recycled to the cell surface. The findings could illuminate cellular processes that go awry in diabetes and point toward new therapeutic approaches. The work combines detailed cell biology with cross-species comparison to understand conserved mechanisms.
Why it matters
Potential benefit: A clearer picture of cellular recycling pathways could inform future diabetes treatments by identifying new targets to repair or optimize protein and lipid trafficking in cells.
How similar studies have gone: Previous studies in model organisms and mammalian cells have advanced understanding of endosomal trafficking, with growing evidence of conservation across species.
Where this research is happening
-
Rutgers, the State Univ of N.j.
Piscataway, United States Active
Researchers
- Principal investigator: Grant, Barth Demian — Rutgers, the State Univ of N.j.
- Study coordinator: Grant, Barth Demian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.