Understanding how rectal Chlamydia trachomatis infections affect immune responses
Official title: Coordinated studies in monkeys and humans to assess the immunological impact of rectal Chlamydia trachomatis infection on protection against genital infection
Funded at University of Washington · NIH-11063193 · Data updated 2026-11-12
This study is looking at how the body’s immune system reacts to rectal chlamydia infections in both monkeys and people, to better understand how these infections might affect the chances of getting reinfected and to help develop better vaccines in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,078,649 |
| NIH project number | 5R01AI175153-03 |
| Project ID | NIH-11063193 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals diagnosed with rectal Chlamydia trachomatis infections or those at high risk for such infections.
✕Less likely to help
Patients who have never been infected with Chlamydia trachomatis or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the immune response to rectal Chlamydia trachomatis (CT) infections in both monkeys and humans. By studying these infections, the research aims to determine how they influence the risk of reinfection and the overall immune response. The approach includes animal studies in nonhuman primates and human participants to gather data on immune responses and potential protective effects. The findings could inform future vaccine strategies against chlamydia.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccine strategies for preventing chlamydia infections.
How similar studies have gone: Previous studies in animal models have shown promising results regarding the immune response to rectal infections, suggesting potential for success in this research.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Patton, Dorothy L — University of Washington
- Study coordinator: Patton, Dorothy L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.