Understanding how recombination rates vary in genetics
Official title: The evolution and genetics of recombination rate variation
Funded at University of California Riverside · NIH-10937808 · Data updated 2026-11-12
This study looks at how genetics and evolution affect the way genes mix during reproduction, which is important for healthy offspring and genetic variety, and it aims to help people understand genetic disorders that can happen when this process goes wrong.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $382,958 |
| NIH project number | 1R35GM154837-01 |
| Project ID | NIH-10937808 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include individuals with chromosomal disorders such as Down's syndrome or Klinefelter syndrome.
✕Less likely to help
Patients with conditions unrelated to chromosomal disorders or recombination errors may not receive any benefit from this research.
What this research studies
This research investigates the genetic and evolutionary factors that influence the rate of recombination, which is crucial for reproduction and genetic diversity. By utilizing advanced genomic tools and studying model organisms like threespine sticklebacks and Drosophila, the research aims to uncover the reasons behind variations in recombination rates. The project will explore how these variations affect genetic inheritance and contribute to chromosomal disorders in humans. Patients may benefit from insights gained about genetic disorders linked to recombination errors.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for genetic disorders caused by recombination errors.
How similar studies have gone: Previous research has shown success in understanding genetic variation through similar genomic approaches, indicating potential for impactful findings in this area.
Where this research is happening
-
University of California Riverside
Riverside, United States Active
Researchers
- Principal investigator: Samuk, Kieran — University of California Riverside
- Study coordinator: Samuk, Kieran
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.