Understanding how reactive oxygen species affect cell signaling
Official title: Molecular mechanisms of cellular redox signaling
Funded at Cornell University · NIH-11004686 · Data updated 2026-11-12
This study is looking at how certain molecules in our cells can both cause damage and help activate helpful processes, which could lead to better ways to treat conditions related to cell stress and injury.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | January 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $344,250 |
| NIH project number | 5R35GM152166-02 |
| Project ID | NIH-11004686 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions related to oxidative stress, such as aging-related disorders or chronic diseases.
✕Less likely to help
Patients with conditions unrelated to oxidative stress or cellular signaling may not receive any benefit from this research.
What this research studies
This research investigates the dual roles of reactive oxygen species (ROS) in cellular processes, focusing on how they can both damage cells and activate beneficial signaling pathways. The study aims to identify specific pathways influenced by ROS through the modification of proteins, particularly cysteine and methionine residues. By characterizing these redox-signaling components, the research seeks to enhance our understanding of how cells manage oxidative stress and develop potential therapeutic strategies. Patients may benefit from insights gained about cellular responses to stress and injury.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for diseases associated with oxidative stress and cellular damage.
How similar studies have gone: Other research has shown promise in understanding redox signaling pathways, indicating that this approach could yield significant insights.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Sevier, Carolyn S — Cornell University
- Study coordinator: Sevier, Carolyn S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.