Understanding how reactive nitrogen species affect bacterial interactions
Elucidating the role of reactive nitrogen species in bacterial interactions
['FUNDING_OTHER'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-10863910
This study is looking at how certain chemicals made by our bodies can help good bacteria fight off bad bacteria, using fruit flies to learn more about how this works and how it might help keep us healthy and prevent infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-10863910 on ClinicalTrials.gov |
What this research studies
This research investigates the role of reactive nitrogen species (RNS) in the interactions between different types of bacteria within complex environments. Using a model organism, Drosophila melanogaster, the study aims to uncover how RNS influence the behavior and dynamics of bacterial communities, particularly in relation to host immunity. By employing advanced techniques such as molecular genetics and systems biology, the research seeks to fill gaps in knowledge regarding how beneficial bacteria can use RNS to outcompete harmful pathogens. The findings could provide insights into maintaining health and preventing infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions influenced by bacterial infections or those interested in understanding the role of gut microbiota in health.
Not a fit: Patients with conditions unrelated to bacterial infections or immune responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses and preventing bacterial infections.
How similar studies have performed: While the role of RNS in single-species models has been studied, this research takes a novel approach by focusing on polymicrobial interactions, which has not been extensively explored.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCOFFIELD, JESSICA A — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: SCOFFIELD, JESSICA A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.