Understanding how RBM12 regulates brain signaling pathways
Official title: Regulation of neuronal GPCR/PKA signaling by RBM12
Funded at Duke University · NIH-11068836 · Data updated 2026-11-12
This study is looking at how a protein called RBM12 helps control important signals in the brain that are linked to various conditions, and it aims to find out if changes in this protein could be connected to brain disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | April 15, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $535,624 |
| NIH project number | 1R01MH139472-01 |
| Project ID | NIH-11068836 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurodevelopmental or neuropsychiatric disorders linked to GPCR signaling dysregulation.
✕Less likely to help
Patients with conditions unrelated to GPCR signaling or those without neurodevelopmental or neuropsychiatric disorders may not benefit from this research.
What this research studies
This research investigates the role of RNA binding motif protein 12 (RBM12) in regulating neuronal signaling pathways mediated by G protein-coupled receptors (GPCRs). By using advanced techniques such as RNA genomics and biochemistry, the study aims to uncover how RBM12 influences GPCR signaling, which is crucial for normal brain function. The research will also explore how genetic variations in RBM12 may affect its function and contribute to neurological disorders. Ultimately, this work seeks to enhance our understanding of the cellular mechanisms that underlie brain signaling and its implications for neurodevelopmental and neuropsychiatric conditions.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the treatment of neurological and neurodevelopmental disorders by targeting GPCR signaling pathways.
How similar studies have gone: Previous research has shown promising results in understanding GPCR signaling pathways, indicating that this approach has potential for significant advancements.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Tsvetanova, Nikoleta Georgieva — Duke University
- Study coordinator: Tsvetanova, Nikoleta Georgieva
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.