Understanding how Raptor affects injury from low oxygen levels
Official title: DEFINING RAPTOR-MEDIATED MECHANISMS OF HYPOXIC INJURY
Funded at University of Washington · NIH-10878881 · Data updated 2026-11-12
This study is looking at how a protein called Raptor helps protect cells from damage when there's not enough oxygen, using tiny worms to see how changes in Raptor can make cells stronger in low-oxygen situations, which could lead to new treatments for related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $639,640 |
| NIH project number | 5R01NS128769-02 |
| Project ID | NIH-10878881 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from conditions that involve hypoxic injury, such as certain types of cancer or respiratory diseases.
✕Less likely to help
Patients with conditions unrelated to hypoxia or those who do not have a genetic predisposition to respond to Raptor-related therapies may not benefit from this research.
What this research studies
This research investigates the role of Raptor, a protein involved in cellular metabolism, in protecting cells from damage caused by low oxygen levels, known as hypoxic injury. Using a model organism called C. elegans, researchers will explore genetic mutations that affect Raptor's function and how these mutations can enhance resistance to hypoxia. The study employs advanced techniques like CRISPR to create specific mutations and assess their impact on cell survival under low oxygen conditions. By understanding these mechanisms, the research aims to uncover potential therapeutic targets for conditions related to hypoxia.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions caused by low oxygen levels, improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the role of mTOR signaling in various diseases, indicating that this approach may yield valuable insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Crowder, C. Michael — University of Washington
- Study coordinator: Crowder, C. Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.