Understanding how rapidly changing proteins affect bacterial infections
Functions of Rapidly-Evolving Proteins and Their Roles in Pathogenicity
['FUNDING_CAREER'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10984730
This study is using smart computer tools to create detailed 3D models of tricky proteins in bacteria that change a lot, helping scientists understand how these proteins work and how they might cause infections, which could lead to better ways to fight bacterial illnesses.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10984730 on ClinicalTrials.gov |
What this research studies
This research investigates rapidly evolving proteins in bacteria, which change their functions and active sites frequently, making them difficult to study. By utilizing advanced artificial intelligence methods, such as AlphaFold, the project aims to create accurate 3D models of these proteins, allowing researchers to better understand their roles in bacterial pathogenicity. The study will also explore protein-protein interactions to gain insights into the functions of these proteins. This innovative approach could lead to breakthroughs in how we understand and combat bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with infections caused by rapidly evolving bacterial pathogens.
Not a fit: Patients with infections caused by stable or non-evolving bacterial strains may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating bacterial infections by targeting rapidly evolving proteins.
How similar studies have performed: Other research has shown promise in using AI and 3D modeling to study protein structures, indicating that this approach could yield significant insights.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, JING — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: ZHANG, JING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.